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Title: No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal Authored by: Paparini, A., Rossi, P., Gianfranceschi, G., Brugaletta, V., Falsaperla, R., De Luca, P., Romano Spica V Abstract:
To analyze possible effects of microwaves on gene expression, mice were exposed to global system for mobile communication (GSM) 1800 MHz signal for 1 hour at a whole body SAR of 1.1 W/kg. Gene expression was studied in the whole brain, where the average SAR was 0.2 W/kg, by expression microarrays containing over 22,600 probe sets. Comparison of data from sham and exposed animals showed no significant difference in gene expression modulation. However, when less stringent constraints were adopted to analyze microarray results, 75 genes were found to be modulated following exposure. Forty-two probes showed fold-changes ranging from 1.5 to 2.8, whereas thirty-three were down-regulated from 0.67 to 0.29 fold-changes, but these differences in gene expression were not confirmed by real-time PCR. Under these specific limited conditions, no consistent indication of gene expression modulation in whole mouse brain, were found associated to GSM 1800 MHz exposure.
Reference: Paparini, A., Rossi, P., Gianfranceschi, G., Brugaletta, V., Falsaperla, R., De Luca, P., Romano Spica V, 2008, No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal, 29:312-323 Keywords: Microarray, mobile phones, electromagnetic fields, radiofrequency, microwave |
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